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Two forms of commercially-available preserved TA (Kenalog-forty, C24H31FO6 MW:434.50; Bristol Myers Squibb; and Transton, C24H31FO6 MW:434.50, Triamcinolone Acetonide Injection; Kunming Jida Pharmaceuticals Co., Ltd.) and one preservative-free TA (Triesence; Alcon Prescription drugs) have been used for this study.
TGF-β1 remedy stimulates the manufacturing of collagen in keloid fibroblasts but not in regular skin fibroblasts ( 1 ). Statement that anti-TGF-β1 antibody suppresses collagen synthesis of keloid fibroblasts additional confirms the position of TGF-β1 ( 1 ). TGF-β2 treatment enhances collagen production of xenograft derived from human keloid specimens in athymic rats, indicating a causative function of TGF-β2 in keloid formation ( 2 ). In distinction, TGF-β2 antibody inhibits collagen generation in xenograft mannequin, suggesting that it could act as a potential antiscarring agent ( 2 ). Interleukin (IL)-13 induces a more rapid improve in collagen generation in keloid fibroblasts compared to regular fibroblasts ( three ).

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